Ashley Young and Luke Shaw are suspended for Manchester United, while Nemanja Matic is a doubt because of illness.
Ander Herrera, Eric Bailly, Alexis Sanchez and Antonio Valencia remain sidelined by injuries.
West Ham winger Michail Antonio returns after missing the defeat at Chelsea because of an ankle problem.
Samir Nasri is absent with a calf injury sustained in the warm-up at Stamford Bridge.
Jack Wilshere is fit again after an ankle injury but will play a second game for the under-23s before making a first-team return.
MOTD COMMENTATOR’S NOTES
@SimonBrotherton: Wednesday night’s reverse to Barcelona was United’s fourth defeat in the last five matches, but they’ll look to get back on track in the race for a top-four finish here against a West Ham side who’ve lost four of the last six in the league.
United’s recent stumble means they start the weekend down in sixth, three points behind Tottenham in fourth.
The Hammers enjoyed an excellent 3-1 win when the teams met at the London Stadium earlier this season. But their recent away form has been awful, which doesn’t bode well for their chances in this one, with United unbeaten at home in the league since August.
VIEW FROM THE DUGOUT
Manchester United manager Ole Gunnar Solskjaer: “We need as many points as possible and I think if we get 15 we’ll be top three, because in those games hopefully we’ll beat Chelsea.
“But now it’s about West Ham and focusing on a good performance to give us three points.
“We want top three. Top four is also an aim if we don’t get 15 points but we should aim for 15.”
West Ham United manager Manuel Pellegrini: “We must demand more. We must try to play every game with improvement and evolve.
“We still have a mathematical chance for Europe and we must try for that.”
United’s performances in their home defeats against Barca, Paris St-Germain and Juventus have shown how far they are off the top clubs in Europe.
They should still have too much for the Hammers, though.
- West Ham could claim a league double against Manchester United for the first time since the 2006-07 season.
- They have only lost two of the past eight league meetings (W2, D4).
- However, United are unbeaten in the last 10 meetings at Old Trafford, winning eight and drawing two.
- United have lost four of their past five matches in all competitions.
- They could lose three consecutive league and cup fixtures for the first time since September 2016.
- The Red Devils have not kept a clean sheet for eight games in all competitions – their longest run since a 10-match sequence in 2012.
- They are unbeaten in 13 home league games (W8, D5), last losing at Old Trafford on 27 August against Tottenham.
- Romelu Lukaku has scored in five successive home appearances against West Ham in the Premier League.
West Ham United
- West Ham have lost three of their past four matches, all by a 2-0 scoreline.
- The Hammers are winless in seven league away games, losing six and scoring just one goal.
- Nine of their last 11 league goals have come from set-pieces.
- West Ham have kept just five Premier League clean sheets this season – only Fulham have recorded fewer.
- Felipe Anderson has eight goals this season but has failed to score in his last 13 Premier League matches.
- Lukasz Fabianski has made a Premier League-high 134 saves this season, 21 more than nearest rival David de Gea prior to the weekend.